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Company: Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Synthetic Molecule Design and Development (SMDD) organization is responsible for the development of synthetic drug substances and drug products from the pre-clinical phase through commercialization. Our scientists and engineers develop innovative technical solutions to advance an exciting portfolio that includes small molecules, synthetic peptides, oligonucleotides, and other emerging therapeutic modalities. By cultivating a hardworking, culturally diverse workforce that exhibits deep technical expertise, SMDD delivers on these responsibilities and helps bring the next generation of life-changing medicines to patients.

Our team is seeking rising technical scientists who are innovative and motivated to apply their strong foundation in analytical sciences to develop robust control strategies, enable clinical trials, regulatory submissions, and new product commercialization. In this role you will have the opportunity to lead analytical efforts within a multidisciplinary team consisting of chemists, formulation scientists, and engineers while offering access to world-class capabilities for pharmaceutical product development. This technical, lab-based role is at the early phase interface with our Lilly Genetic Medicines (LGM) discovery team and will be co-located at our new research facility opening in Boston Seaport in mid-2024. This role will emphasize identification of emerging analytical needs to enable the LGM portfolio, including development and execution of research plans with a cross functional team to help accelerate programs and facilitate technical transfer to the early phase clinical supply team located in Indianapolis.


Top candidates for this position will be expected to:

  • Apply high-resolution mass spectrometry in the structural and biophysical characterization of therapeutic oligonucleotides and bioconjugates.
  • Drive the implementation of technical solutions and analytical strategies to enable synthetic chemistry, process engineering, formulation design, and continuous manufacturing.
  • Creative mindset with the ability to craft a vision for a team of innovative analytical chemists, adopting and implementing new technologies to accelerate and deliver the genetic medicines portfolio.
  • Demonstrate high learning agility and the ability to understand and exploit effective scientific concepts and methods across multiple subject areas (e.g., chemistry, pharmaceutical sciences, PAT, and modeling and simulation); be able to use these techniques to bring value across a portfolio of synthetic oligonucleotides and bioconjugates.
  • Possess prior experience leading analytical efforts focused on pharmaceutical development and commercialization, as well as demonstrate familiarity with applicable regulatory requirements and emerging trends in the industry.
  • Provide technical guidance for analytical activities executed within the external network. Ensure methods are technically sound, well developed and characterized. Execute technology transfer to CRO/CMO organizations and Lilly manufacturing sites.
  • Mentor and develop scientific staff. Ensure continued technical and professional growth of group members, encourage efforts towards excellence and knowledge sharing.
  • Collaborate closely with organizations across Development and Manufacturing to execute and deliver material and information for clinical trials and regulatory submissions.
  • Embrace diverse thought, background, and experience to deliver innovative solutions.
  • Possess strong communication (oral, written), organizational, and leadership skills.
  • Actively engage in the external environment and the ability to recognize and apply external innovation across the Lilly synthetic portfolio.

Basic Qualifications:

  • Ph.D. in analytical chemistry or bioanalytical chemistry, or a related field with 5+ years of experience in the pharmaceutical industry or alternatively a B.S. in chemistry with 15+ years (or M.S. in chemistry with 10+ years) of experience in the pharmaceutical industry

Additional Skills/Preferences:

  • Proficiency in LC-MS and UHPLC method development and data analysis
  • Experience with small scale purification, MALS, enzymatic digestion techniques
  • Experience with technical transfer of analytical methods into manufacturing operations
  • Strong technical skills to enable innovation which creates business value.
  • Creativity and ability to transform ideas into marketable products and processes.
  • Knowledge and experience with management of a technical project
  • Demonstrated leadership capabilities especially in a team environment.
  • Demonstrated ability to drive and accept change.
  • Demonstrated success in persuasion, influence, and negotiation.
  • Good interpersonal skills and a sustained tendency for collaboration
  • Ability to prioritize multiple activities and manage ambiguity.
  • Ability to influence others to promote a positive work environment.
  • Demonstrated technical proficiency and ability to create ideas for future work plans.

Additional Information:

  • Travel: 5-10%
  • Position Local: Cambridge, MA.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.


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