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Full-time

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Company: Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly Neuroscience is seeking a dedicated scientist to join Neuroscience Discovery/Neurodegeneration Group to facilitate its mission of discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, and other related neurodegenerative conditions. You will contribute to research focused on developing therapeutics in close collaboration with other Neurodegeneration laboratories as well as Lilly’s chemistry and biotherapeutic engineering divisions. A substantial focus of the role will be the supporting development and implementation of in vitro/in vivo blood brain barrier (BBB) receptor-mediated transport models for protein and oligonucleotide based therapeutics. Do you possess hands-on laboratory experience, a keen interest to understand the molecular and cellular mechanisms that underlie non-invasive drug delivery to the CNS, and have an outstanding attention to scientific detail? This role would be a great fit.

Key Objectives:

  • Develop primary neuron and primary microglia cell culture assays to understand receptor targeted drug efficacies in vitro and ex vivo.
  • Routinely perform RT-qPCR and ELISA assays to assess PKPD target engagement and efficacy of systemically administered antibody drug/siRNA conjugates in plasma and in tissues.
  • Perform high throughput imaging and analysis of cell cultures to assess drug target engagement
  • Analyze changes in gene and protein expression from cell cultures, brain and peripheral tissues by RT-qPCR, ELISA
  • Develop and troubleshoot assays independently, record, analyze and communicate scientific data.

Basic Qualifications

  • Bachelor’s or Master’s Degree in Biochemistry, Molecular and Cellular Biology, Neuroscience or a related field.
  • 5+ years’ work experience with routine assay development.

Additional Skills/Preferences

  • Experience in harvesting and growing primary neurons, primary microglia or culturing and differentiating iPSC neurons to develop/perform/problem solve mammalian cell culture functional assays.
  • Robust experience in developing ELISA assays independently
  • Experience in utilizing high content imaging equipment (e.g. Cytation 5, Opera, Operetta) to image cell cultures and generating study reports.
  • Experience in using liquid handlers to automate RT-qPCR and ELISA assays.
  • Problem-solving skills and creativity with a willingness to search and review the scientific literature independently.
  • Have accurate and timely record keeping and strong data analysis and organizational skills.
  • Able to clearly communicate data and work independently in order craft and troubleshoot experiments.
  • Experience in the area of Neurodegenerative disease
  • Experience with in vitro and in vivo assay development for drug discovery in industry.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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