Human Genetics Lead – Diabetes, Obesity and Complications

Industry:

Company: Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$153,750 – $270,600

The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) focuses on new therapeutic approaches for the treatment of diabetes, obesity and cardiometabolic diseases. Starting from an idea, we work with partners across Lilly to discover and develop novel biologic, small molecule and nucleic acid-based therapeutics. Our focus is the patient: by understanding the biology and pathophysiology underlying disease states, we aim to address the root cause of disease, and develop breakthrough therapies. We have one of the strongest pipelines in the industry and a track record of delivering impactful medicines that improve people’s lives.

We are seeking a transformative Human Genetics Lead – Diabetes, Obesity, and Complications within the DOCTA organization. This role will drive our human genetics research forward. We need a forward-thinking, passionate, and collaborative leader with deep knowledge of human genetics and metabolic disease biology. The Human Genetics Lead will build and lead a diverse team of in-house geneticists. You will establish a vibrant network with the external scientific community. Represent the Data Science and Computational Biology (DSCB) group and DOCTA both internally and externally. Partner with key opinion leaders and identify strategic alliance opportunities in human genetics and metabolism. Under your leadership, the Human Genetics group within DSCB will impact disease target identification, indication expansion, subpopulation classification, and disease mechanism understanding. Use Lilly’s large in-house datasets and disease state expertise to address scientific questions. Push the boundaries of scientific innovation. Work across research and clinical groups within DOCTA and Eli Lilly in one of the most exciting and dynamic fields of research today.

Are you interested in a unique opportunity to help build and advance a life-changing portfolio of medicines? Appy today to join Team Lilly!
Key Responsibilities:

• Provide scientific leadership and strategic vision in human genetics to position Lilly at the forefront of genetics for diabetes, obesity, and complications
• Build, lead, and mentor a diverse team with expertise in statistical/population genetics, genomics, and genetic epidemiology
• Develop and implement an innovative model for execution on strategic priorities, including managing internal hires, postdoctoral fellows, contractors, vendors, and strategic partners
• Design and implement a visiting scholar program for senior-level human genetics researchers
• Develop and implement strategies to optimally use public large-scale genetic and genomic resources. Integrate population-scale biobanks and genome sequencing initiatives with patient-derived data from clinical trials. Provide novel insights for Lilly’s portfolio.
• Align with DOCTA’s strategic priorities and drive data-driven innovative approaches to identify and validate novel therapeutic targets
• Spearhead cross-functional initiatives to translate genetic/genomic findings into actionable insights that inform drug discovery, biomarker development, and clinical trial design
• Lead ongoing and new strategic collaborations to access unique genetic data assets and amplify research capabilities
• Represent Lilly at scientific conferences and engage with the broader genetics/genomics community to stay at the forefront of innovation
• Partner with internal teams to evaluate external innovation opportunities and bring insights to aid decision making
• Interpret and clearly communicate results from genetic analyses. Develop scientific manuscripts, posters, and presentations. Communicate the group’s vision and progress to internal and external partners.
• Implement industry-standard standard methodologies for scientific project execution and documentation (e.g., JIRA, Confluence, Git, code review, and other documentation tools)
• Accountable for the team’s development and documentation of reproducible pipelines for genetics analyses
• Perform hands-on execution of human genetic analyses as needed
• Foster a culture of scientific excellence, collaboration, and continuous learning within the human genetics and bioinformatics group and across the organization

Minimum Requirements:

• PhD or equivalent in Human Genetics, Statistical Genetics, or related field
• At least 4 years industry experience, including 3 years in a leadership role.

Additional Skills/Preferences:

• Demonstrated success in building, mentoring, and managing scientific teams (3+ years managing direct reports required)
• Deep prior experience with multiple in human genetics workflows including analysis of WGS, WES, and genotyping data for association analyses, polygenic risks score analysis, and analysis of rare variants, required
• Prior experience working with clinical and observational biomedical informatics data sets, including data from clinical trials, EHRs, and large biobanks (e.g., UKBB), required
• Led or played a significant role in high-impact research programs in pharma, biotech, or academia; knowledge of drug development strongly preferred
• Prior experience with clinical/diagnostic genetics, including application of ACMG criteria for annotation of variant pathogenicity, strongly preferred
• Strong track record of publications in top-tier journals
• Strong collaborative approach with outstanding communication and interpersonal skills to engage cross-functional teams and external partners
• Ability to prioritize and manage multiple competing priorities within a fast-paced environment
• Demonstrated ability to lead and manage successfully within a matrixed organization
• Strongly team-oriented with a customer focused design thinking approach

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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