Advisor, Mass Spectrometry, BR&D

Industry:

Company: Eli Lilly and Company

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

The Bioproduct Research and Development (BR&D) organization delivers new medicines to patients through the development and commercialization of insulins, peptides, oligonucleotides, monoclonal antibodies, novel therapeutic proteins, and gene therapy systems. BR&D is a multidisciplinary group with deep technical expertise that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, IN, scientists have full access to Lilly’s deep pharmaceutical development expertise and engineering capabilities.

Position Summary:

We are looking for a motivated scientist with deep expertise in mass spectrometry to join our Structural Characterization Team. The successful candidate will develop and apply LC-MS methods to enable innovations in process and product development and analytical control strategy for diverse classes of biotherapeutics including complex yet promising new therapeutic modalities such as bioconjugates, peptides and oligonucleotides etc.

Key Responsibilities:

• Conduct in-depth structural characterization of complex therapeutic molecules using mass spectrometry.
• Design, development, qualification and validation, and transfer of innovative LC-MS methodologies for the characterization and analysis of antibody-drug conjugates, antibody-oligonucleotide conjugates, peptides and co-formulation products etc.
• Innovate to improve core technologies and build next-generation mass spectrometry characterization capabilities.
• Engage with scientists across development and manufacturing as well as external development partners to design and implement control strategies for projects at various stages of development.
• Partner closely with colleagues across Lilly, including the Structural Characterization Team, other groups in BRD, Synthetic Molecule Design and Development, ADME/Toxicology/PKPD, Clinical, and Manufacturing.
• Author IND/CTA, BLA/NDA/MAA, and country-specific Response to Questions (RtQ).
• May supervise and develop other analytical scientists.
• Actively engage with the broader scientific community by reading scientific and trade literature, attending/presenting at meetings and conferences, and authoring original research publications. Identify, champion, and deliver opportunities to create value from the external environment.

Basic Requirements:

• Ph.D. in analytical chemistry or a related field, or alternatively a B.S. in chemistry with 10+ years (or M.S. in chemistry with 5+ years) of experience in the pharmaceutical industry.
• Expertise and hands-on experience in protein characterization using mass spectrometry.

Additional Preferences:

• Experience with characterization of antibody-drug conjugates or antibody-oligonucleotide conjugates, synthetic peptides, oligonucleotides and co-formulation products using mass spectrometry.
• Experience with chromatography or capillary electrophoresis separation methods for analysis of complex biomolecule samples.
• Experience with analytical method development, qualification/validation, and transfer of analytical methods to QC labs.
• Experience with authoring regulatory submissions and responding to regulatory questions.
• Ability to carry out research programs independently and to collaborate effectively with others.
• Strong communication (oral, written), organizational, interpersonal, and leadership skills.
• Must be able to work productively in an interdisciplinary team environment.

Additional Information:

• Potential exposure to chemicals, allergens, and loud noises.
• Travel: 0 to 15%
• Position Location: Indianapolis, IN; Lilly Technology Center-North (LTC-N).

Physical Demands/Travel:

The physical demands of this job are consistent with a lab environment

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

This position’s work environment is in a Laboratory.

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

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